The Queen's College Crest

The Queen’s College

University of Oxford

Prof Chris Norbury

Senior Tutor, Official Fellow and Tutor in Medical Sciences

Email: chris.norbury@queens.ox.ac.uk

Tel: (01865) 275540

Faculty webpage: http://users.ox.ac.uk/~path0204/

 

Introduction

I went to school in Coventry, and then studied Biochemistry at Oxford before completing a PhD at Imperial College while carrying out research at the Imperial Cancer Research Fund (now Cancer Research UK) laboratories in London. I then worked as a postdoctoral fellow with Professor (now Sir) Paul Nurse for six years, before setting up my own research group at the Weatherall Institute of Molecular Medicine back in Oxford. In 2002 I moved my group to the Sir William Dunn School of Pathology and took up a Tutorial Fellowship at Queen’s. I previously served as Tutor for Admissions, and have been Senior Tutor since October 2010.

 

Teaching

I teach a variety of aspects of cell and molecular biology, biochemistry, medical genetics and general pathology to students of Medicine and Biomedical Sciences in their first two years. I also organise the FHS (third year) option in Molecular Medicine and teach those aspects of the option that relate to cancer biology, as well as supervising research students in my laboratory at the Dunn School.

 

Research

My doctoral research was in tumour virus genetics, and I have been working on various aspects of the cell and molecular biology of cancer ever since. My research group, based since 2011 in the Dunn School’s new Oxford Molecular Pathology Institute, is currently investigating post-transcriptional aspects of gene regulation, and specifically how these differ between cancer cells and their normal counterparts.

 

Selected publications

  • Schmidt, M-J., West, S. and C. J. Norbury. 2011. The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation. RNA 17: 39-44.
  • Grzmil, M., T. Rzymski, M. Milani, A. L. Harris, R. G. Capper, N. J. Saunders, A. Salhan, J. Ragoussis, and C. J. Norbury. 2010. An oncogenic role of eIF3e/INT6 in human breast cancer. Oncogene 29:4080-4089.
  • Rissland, O. S., and C. J. Norbury. 2009. Decapping is preceded by 3′ uridylation in a novel pathway of bulk mRNA turnover. Nature Struct Mol Biol 16: 616-623.
  • Norbury, C. J. 2005. The cancer cell cycle. pp 156-169 In M. Knowles and P. Selby (eds), Cellular & Molecular Biology of Cancer. Oxford University Press.

For a fuller list see: http://users.ox.ac.uk/~path0204/pubs.html